Figure 2. Effect of angiotensin II on hOAT3 activity.
hOAT3-expressing cells were treated with angiotensin II at various periods of time (A), or at various concentrations (B), followed by [3H] estrone sulfate uptake (3 min, 0.1 μM). Uptake activity was expressed as a percentage of the uptake measured in untreated cells. The results represent data from 3 experiments. The uptake values in mock cells (parental COS-7 cells) were subtracted. Values are means ± S.D. (n = 3).