Table 1.
Histopathological evaluation of wound healing process in different treatment groups.
| Groups | Wound healing process | |||||||
|---|---|---|---|---|---|---|---|---|
| S | U | Ed | PMC | MNC | FP | RE | CD | |
| Day 7 | ||||||||
| Nontreated | ++ | ++ | ++/+ | +++ | + | +/− | − | − |
| Vehicle control | +++ | ++/+ | ++ | +++/++ | + | + | − | −/+ |
| CvME (2.5%) | + | − | − | ++ | ++/+++ | ++ | + | ++ |
| Gentamicin sulfate (0.01%) | + | − | − | ++ | ++ | ++ | + | ++ |
| Day 15 | ||||||||
| Nontreated | + | + | − | ++ | +++ | ++ | + | ++ |
| Vehicle control | + | + | − | ++ | +++ | ++ | ++ | ++ |
| CvME (2.5%) | − | − | − | −/+ | + | +++ | +++ | +++ |
| Gentamicin sulfate (0.01%) | − | − | − | −/+ | + | +++ | +++ | +++ |
HE and MT staining were scored as mild (+), moderate (++), and severe (+++) for epidermal and/or dermal remodeling. S: scab; U: ulcer; Ed: edema; PMC: polymorphonuclear cells; MNC: mononuclear cells; FP: fibroblast proliferation; CD: collagen deposition; RE: reepithelialization; CvME: C. viscosa methanol extract.