Figure 1.

Hyperglycemia contributes to malignant cancer cell phenotypes. There is increasing evidence suggesting that there is a link between cancer and diabetes mellitus. Regardless of other shared metabolic factors, hyperglycemia, the most typical characteristic of diabetes, may be one reason to explain the prevalence of cancer incidence in patients with diabetes mellitus. Research shows that hyperglycemia may contribute to an enhanced proliferation ability, apoptosis inhibition, metastasis, perineural invasion, chemotherapy resistance, and chemotherapy intolerance.