Table 1.
Clinical characteristics of T2DM patients with and without DN.
| Characteristics | Healthy controls (85*) | DM without DN (86) | DN before treatment (92) | DN after treatment (92) | P 1 | P 2 | |
|---|---|---|---|---|---|---|---|
| Well controlled (80) | Not well controlled (12) | ||||||
| Sex (M : F) | 36 : 49 | 47 : 39 | 57 : 35 | 50 : 30 | 7 : 5 | 0.62 | 0.75 |
| Age (years ± SD) | 52.1 ± 5.6 | 49.3 ± 4.7 | 50.3 ± 7.4 | 51.2 ± 6.3 | 49.5 ± 8.5 | 0.72 | 0.83 |
| BMI Kg/m2 | 24.07 ± 1.21 | 23.45 ± 1.02 | 23.17 ± 0.98 | 24.58 ± 1.16 | 23.66 ± 1.32 | 0.68 | 0.83 |
| SBP (mmHg) | 128.4 ± 10.6 | 129.7 ± 13.2 | 130.5 ± 11.7 | 127.8 ± 12.6 | 129.8 ± 12.9 | 0.89 | 0.93 |
| DBP (mmHg) | 78.2 ± 8.7 | 79.1 ± 6.9 | 80.4 ± 8.5 | 78.4 ± 7.4 | 75.3 ± 9.3 | 0.92 | 0.87 |
| Fasting glucose (mmol/L) | 3.98 ± 0.77 | 8.37 ± 3.46 | 5.32 ± 0.25 | 4.81 ± 2.32 | 4.54 ± 3.17 | <0.05 | 0.79 |
| HbA1c (%) | 5.31 ± 0.32 | 8.61 ± 0.75 | 6.26 ± 0.54 | 6.07 ± 0.61 | 6.72 ± 0.45 | <0.05 | 0.82 |
| AlbU (g/L) | 8.32 ± 3.5 | 10.32 ± 2.8 | 437.2 ± 164.6 | 21.36 ± 8.3 | 389.7 ± 45.2 | <0.05 | <0.05 |
| Cys-c (mg/L) | 0.62 ± 0.17 | 0.71 ± 0.21 | 1.48 ± 1.15 | 0.67 ± 0.08 | 1.45 ± 0.78 | <0.05 | <0.05 |
| UREA (mmol/L) | 4.24 ± 1.32 | 3.98 ± 1.27 | 6.78 ± 1.90 | 4.02 ± 1.13 | 5.79 ± 1.82 | <0.05 | <0.05 |
| CREA (mmol/L) | 53.44 ± 8.26 | 59.56 ± 7.48 | 86.43 ± 21.34 | 54.67 ± 7.14 | 84.23 ± 19.43 | <0.05 | <0.05 |
| miR-126 [lg2(50-Ct)] | 3.25 ± 0.45 | 3.76 ± 0.38 | 5.76 ± 0.33 | 3.89 ± 0.52 | 5.24 ± 0.47 | <0.05 | <0.05 |
*Indicates numbers of subjects in the group. DM: diabetes mellitus; DN: diabetic nephropathy; SBP: systolic blood pressure; DBP: diastolic blood pressure; Hb Alc-A: glycosylated hemoglobin; AlbU: urine albumin; Cys-c: serum cystatin C; CREA: serum creatinine; P 1: comparison to healthy controls, DM without DN, and DN before treatment. P 2: comparison between DN patients well controlled versus not well controlled by the treatment.