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Interactions between the DHFR protein and the RAB1 (R = n–Pr) inhibitor. This structure illustrates the position of substituents R at the C1 stereocenter of the dihydrophthalazine with a black oval; selected residues are labeled. It is hypothesized that the superior potency of compound 6e (R = cyclopropyl) results from stacking interactions with the guanidinium group of Arg 53.
