Figure 1. Targeted hybrid capture sequencing identified somatic mutations in 70% of BALL patients.
Matched tumor-remission samples from 60 pediatric B-ALL were sequenced with targeted hybrid capture and somatic mutations in any tumor sample were identified. Genes on the left are organized by mutational frequency. The type of alteration is identified for each mutation as frameshift/stop, missense or splice site mutation. MLL: MLL rearranged, HYPO: Hypodiploidy, iAMP21: intrachromosomal amplification of chromosome 21, HYPER: Hyperdiploidy.