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White blood cell (WBC) counts are depressed during pneumococcal infection in EP3−/− mice. Cell counts were enumerated in blood samples taken before infection (A) or 24 hr after infection (B) with S. pneumoniae in wild-type (WT) and EP3 knockout (KO) mice. Lymph, lymphocytes; mono, monocytes; PMN, polymorphonuclear leukocyte (neutrophil). **P < 0.01, *P < 0.05 compared to WT counts.
