Skip to main content
. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Neurobiol Learn Mem. 2013 Nov 11;113:69–81. doi: 10.1016/j.nlm.2013.11.002

Figure 8. Increased immediate-early gene expression in fluoxetine-treated S1 mice.

Figure 8

(A) Freezing during extinction retrieval was significantly lower in fluoxetine (FLX)-treated mice than water controls. (B) Zif268-labeled tissue showing anatomical demarcation of IL and PL and the layers within each region. (C) Examples of Zif268-labeled tissue in layer II of the IL in FLX-treated mice and water controls. (D) The number of Zif268-labeled cells after extinction retrieval was significantly higher in layer II of the IL in FLX-treated mice relative to water controls. (E) The number of Zif268-labeled cells in layer II of the IL did not significantly correlate with the post-CS firing of vmPFC single-units during extinction retrieval. (F) The number of Zif268-labeled cells following extinction retrieval did not significantly differ between water and fluoxetine-treated mice in any layer of PL, although a trend was evident in layer II. (G) The number of Zif268-labeled cells in layer II of PL did not significantly correlate with the post-CS firing of vmPFC single-units during extinction retrieval. n=5–8 mice per treatment. Data are Means ± SEM. * P<.05 versus water in the same task-phase or layer. Data are Means ± SEM.