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. 2014 May 8;54(3):472–484. doi: 10.1016/j.molcel.2014.03.014

Figure 1.

Figure 1

Slx4-Deficient Mice Are Cancer Prone and Have a Compromised HSPC Pool

(A) Kaplan-Meier curve showing the tumor-free survival of our cohort of aged Slx4f3/f3 C57BL/6NTac mice (n = 28) and congenic controls (n = 28).

(B) Hematoxylin and eosin staining of sections of liver in (1) 8-week-old and (2) 24-week-old Slx4f3/f3 mice, revealing karyomegaly and steatosis. (3) Gross pathology of a typical hepatic mass in Slx4f3/f3. (4) Histology of Slx4f3/f3 hepatic mass, showing a primary hepatocellular cancer.

(C) (1) Low-power magnification of an anal mass (black arrow), and (2) higher magnification shows features of a typical squamous cell carcinoma with keratin whorls of the rectum.

(D) Flow cytometry analysis of total bone marrow from Slx4+/+ and Slx4f3/f3 mice stained with hematopoietic stem and progenitor cell markers (Linage−c-kit+Sca1+: LKS box).

(E) Spleen colony forming assay (CFU-S10) was performed in lethally irradiated recipients revealing a reduction in the Slx4f3/f3 bone marrow. Error bars represent SEM. ∗∗∗∗p < 0.0001.