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. 2014 Feb 14;28(5):510–520. doi: 10.1038/eye.2014.13

Table 1. National Health and Medical Research Council hierarchy of evidence-based scientific studies.

Level Intervention
I A systematic review of level II studies
II A randomized controlled trial
III-1 A pseudorandomized controlled trial (ie, alternate allocation or some other method)
III-2 A comparative study with concurrent controls:  Non-randomized experimental trial  Cohort study  Case–control study  Interrupted time series with a control group
III-3 A comparative study without concurrent controls  Historical control study  Two or more single-arm study  Interrupted time series without a parallel control group
IV Case series with either post-test or pretest/post-test outcomes