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Macrophages act as local sensors and regulators of electrolyte composition in the skin interstitium. Macrophages are attracted to tissues with high concentrations of salt. Under these conditions NFAT5 is activated in macrophages. NFAT5 then drives the expression of vascular endothelial growth factor C (VEGFc), resulting in the hyperplasia of skin lymph capillaries. This results in the clearance of electrolytes from the skin and subsequently a reduction in blood pressure.
