Figure 3.

Integration of functional assays across organisms. One can use functional tools across a variety of organisms, depending upon the model under study and the end goal of the investigation. For example, one may start with a screen in yeast, mouse, or human cells and extend the analyses to whole organisms such as zebrafish or rodents. Alternatively, one may start with zebrafish mutants or DT40 avian deletion cells and perform follow-up experimentation in human cells or other whole organisms. The many possibilities can advance the future of toxicity testing.