Table 2.

Summary of functional toxicological screens in organisms other than yeast.

Chemical/condition	Organism	Methodology	References
Clotrimazole	C. albicans	Deletions	Oh et al., 2010a
Wide variety of growth conditions and diverse chemical compounds	C. albicans	Deletions	Oh et al., 2010b
Paraquat	C. elegans	RNAi	Kim and Sun, 2007
Cell cycle inhibitors	D. melanogaster	RNAi	Eggert et al., 2004
Cell cycle inhibitors	D. rerio	Morpholinos	Murphey et al., 2006
Various media and growth inhibitors	E. coli	Deletions	Warner et al., 2010
Vemurafenib	H. sapiens	CRISPR	Shalem et al., 2014
6-thioguanine	H. sapiens	CRISPR	Wang et al., 2014
Etoposide	H. sapiens	CRISPR	Wang et al., 2014
Wide range of drugs	H. sapiens	RNAi	reviewed by Berns and Bernards (2012)
Ricin	H. sapiens	shRNA	Bassik et al., 2013
3-bromopyruvate	H. sapiens	Transposon mutagenesis	Birsoy et al., 2013
Tunicamycin	H. sapiens	Transposon mutagenesis	Reiling et al., 2011
2-amino-6-mercaptopurine	M. musculus	Transposon mutagenesis	Leeb and Wutz, 2011
6-thioguanine	M. musculus	Transposon mutagenesis	Pettitt et al., 2013
Olaparib	M. musculus	Transposon mutagenesis	Pettitt et al., 2013
Ricin	M. musculus	Transposon mutagenesis	Elling et al., 2011
Wide variety of growth conditions and diverse chemical compounds	S. oneidensis	Deletions	Deutschbauer et al., 2011
Minimal media	S. oneidensis	Deletions	Oh et al., 2010a
Plant hydrolysate	Z. mobilis	Deletions	Skerker et al., 2013

A literature search identified published screens.