Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Amino acid depletion and catabolite production have profound downstream effects on tumor and immune cells by triggering pathways that impact cell growth, proliferation, survival and cellular stress responses. Trp catabolites activate the AhR pathway but metabolites produced by other enzymes depicted may mediate critical effects via other pathways
