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. Author manuscript; available in PMC: 2014 May 12.
Published in final edited form as: Open J Genet. 2013 Dec;3(4):243–252. doi: 10.4236/ojgen.2013.34027

Table 1.

Results od FBAT and GC analyses for alcohol dependence in generations I and II with any substance use disorder coded as positive for generation III.

Marker cM Informativef
amilies
FBAT		 FBAT
p-valuec 		GC
p-value		 Major/
Minor
Allelea 		Nucleotideb Major
Allele
Frequency		 Minor
Allele
Frequency		 Allele
Freq.
Affected		 Allele Freq.
Unaffected		 Gene Location
rs12094153 184.7521 44 0.591 0.584 1 G G = 0.522 A = 0.478 0.603 0.397 TNN
rs4651322 184.7578 41 0.438 0.310 1 C C = 0.673 T = 0.327 0.615 0.385 TNN
rs12563833 184.7603 40 0.065 0.051 2 A G = 0.743 A =0.257 0.289 0.711 TNN
rs1018829 184.7605 35 0.086 0.389 1 G C = 0.832 T = 0.168 0.770 0.230 TNN
rs2018318 184.7636 33 0.177 0.488 1 C G = 0.826 T = 0.174 0.791 0.209 TNN
rs6701037 184.7660 43 0.526 0.512 1 A C = 0.518 A = 0.482 0.566 0.434
rs10912899 184.7663 44 0.021 0.255 2 T G = 0.650 A = 0.350 0.411 0.589
rs6425323 184.7686 43 0.469 0.506 1 C T = 0.518 C = 0.482 0.570 0.430
rs1057302 184.7693 43 0.469 0.540 1 A C = 0.513 T = 0.487 0.575 0.425 KIAA0040 Exon 5
rs2269650 184.7715 45 0.037 0.076 2 A C = 0.677 A = 0.323 0.336 0.664 KIAA0040 Exon 5
rs1057239 184.7719 43 0.604 0.160 1 G T = 0.509 C = 0.491 0.559 0.441 KIAA0040 Exon 5
rs1894709 184.7735 43 0.497 0.098 1 G A = 0.509 C = 0.491 0.557 0.443 KIAA0040 Intron 4
rs2269655 184.7759 35 0.272 0.617 1 G G = 0.881 T = 0.119 0.824 0.818 KIAA0040
rs2861158 184.7761 37 0.033 0.052 2 A G = 0.743 A = 0.257 0.245 0.755 KIAA0040 Exon 4
rs16847872 184.7780 35 0.266 0.648 1 T A = 0.881 G = 0.119 0.836 0.164 KIAA0040 Intron 3
rs1008459 184.7877 37 0.006 0.013 2 G A = .0735 G = 0.265 0.268 0.732 KIAA0040 Intron 2
rs2272785 184.7955 38 0.015 0.031 2 A C = 0.712 A = 0.288 0.268 0.733 KIAA0040 Intron 2
rs3753555 184.7964 45 0.021 0.082 2 G A = 0.588 C = 0.422 0.448 0.552
a

1, major and 2, minor allele (designation based on NCBI build 37.3 allele frequencies for European Caucasians).

b

Bolded nucleotides are the reverse strand.

c

Using a more restrictive phenotype for Generation III that included only alcohol abuse and alcohol dependence p-values are: rs10912899, p = 0.035; rs2269650, p = 0.033; rs2861158, p = 0.037; rs1008459, p = 0.014; rs2272785, p = 0.062; rs3753555, p = 0.020.