Table 1.
Parameters and values incorporated into the model
| Parameter | Symbol | Value |
|---|---|---|
| HIV-1 | ||
| Radius | rHIV | 50 nm |
| Diffusivity in semen | Dv0 | 1.27 μm2/s |
| Diffusivity in CVM | Dvn | αnDv0 |
| Viral load in semen | 8.4 × 105 copies/ejaculate | |
| Number of Env trimer spikes | N∗ | 14 ± 7 (SD) |
| bnAb (IgG) | ||
| Ab-mucin affinity | α | Variable |
| Diffusivity in semen | DAb | 40 μm2/s |
| Diffusivity in CVM | αDAb | Variable |
| Initial Ab concentration in CVM (NIH45-46) | [NIH45-46] | Variable |
| Ab-Env affinity (NIH45-46) | kon, koff | 4.26 × 104, 2.87 × 10−4 |
| Vagina | ||
| Surface area of lumen | SAvagina | 145 cm2 |
| Volume of luminal CVM | VCVM | 750 μL |
| Thickness of CVM Layer | HCVM | 50 μm |
| Volume of semen | Vsemen | 3.0 mL |
| Thickness of semen layer | Hsemen | 200 μm |