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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: J Child Neurol. 2013 Sep;28(9):1159–1168. doi: 10.1177/0883073813494480

Figure 1.

Figure 1

Ppt1−/− mice develop a motor coordination deficit that becomes significant at 32 weeks.

An accelerating rotarod (0-40 rpm in 120 seconds) was used to measure the motor skills of Ppt1−/− and wild-type (WT) mice beginning at the age of 4 weeks. Data points represent mean ± S.E.M. of the time mice were able to stay on the rod. Two-way ANOVA with Bonferroni’s posttest for multiple comparisons was used to determine statistical significance (*P < 0.001, **P <0.0001). Five wild-type mice were assessed at all time points. The experiment started with 9 Ppt1−/− mice, but that number decreased over time due to mouse death (n = 9 through 30 weeks; 31 and 32 weeks, n = 8; 33 weeks, n = 7; 34 weeks, n = 4; 35 weeks, n = 3).