Table 1. Granuloma formation and M. avium dissemination in HO-1-/- and HO-1+/+ mice.
Test/Parameter | HO-1-/- (n=8) | HO-1+/+ (n=8) |
---|---|---|
Granuloma size | 29 ± 10 μm | 1100 ± 102 μm |
Granuloma number | 3 ± 1 | 16 ± 5 |
Morphometric index | 1 ± 0.5 | 10 ± 0.2 |
M. avium dissemination (to liver, spleen) | cultures positive | cultures negative |
Mortality | 50% by 6 weeks | None by 6 weeks |