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Global mutations in the Pf chloroquine resistance transporter gene (PfCRT). The 61 SNPs (18 non-synonymous) identified in PfCRT (Chromosome 7, PF3D7_0709000) are shown. Some markers (eg, Q271E) show evidence that they have gone to fixation in SEA (blue on the left axis) and are common throughout the rest of the world (WAF: green; EAF: yellow; OCE: purple on the left axis). Six known drug resistance markers are shown, as well as 3 common SNPs located in intronic regions (IT).
