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PfRH5 vaccine candidate in chromosome 4. The Pf Reticulocyte Binding Protein Homologue 5 (PfRH5, PF3D7_0424100) gene is considered a promising vaccine candidate, as it seems to be essential for blood-stage parasite invasion of red blood cells [20]. The locus contains 28 SNPs, including 5 non-synonymous mutations with MAF >10% (I410M, S197Y, H148D, Y147H [19] and K419N [20]).
