Table 2.
Type and Number of Serotypes Shed by Subjects Who Acquired OPV Virus Through Direct Vaccination vs Community Spread
| Direct Vaccination (n = 64) |
Community Acquisition (n = 78) |
||||||
|---|---|---|---|---|---|---|---|
| Serotype shed | n | % | 95% CIa | n | % | 95% C.I.a | P Value* |
| Any Type 1 | 25 | 39.1% | 28.0%–51.3% | 4 | 5.1% | 2.1%–11.2% | <.0001 |
| Any Type 2 | 35 | 54.7% | 42.6%–66.3% | 68 | 87.2% | 77.8%–93.1% | <.0001 |
| Any Type 3 | 38 | 59.4% | 47.1%–70.6% | 10 | 12.8% | 6.9%–22.2% | <.0001 |
| Shedding by No. of Serotypes | |||||||
| One serotype | 38 | 59.4% | 47.1%–70.6% | 74 | 94.9% | 87.2%–98.4% | <.0001 |
| Type 1 only | 9 | 14.1% | 7.4%–24.8% | 2 | 2.6% | .2%–9.4% | .0009 |
| Type 2 only | 12 | 18.8% | 10.1%–30.1% | 64 | 82.1% | 72.0%–89.1% | <.0001 |
| Type 3 only | 17 | 26.6% | 17.2%–38.6% | 8 | 10.3% | 5.0%–19.2% | <.0001 |
| Two serotypes | 18 | 28.1% | 18.5%–40.2% | 4 | 5.1% | 1.6%–12.8% | .0003 |
| Type 1 and 2 | 5 | 7.8% | 3.0%–17.4% | 2 | 2.6% | .2%–9.4% | .016 |
| Type 1 and 3 | 3 | 4.7% | 1.1%–13.4% | 0 | 0.0% | .0%–5.6% | .56 |
| Type 2 and 3 | 10 | 15.6% | 8.5%–26.6% | 2 | 2.6% | .2%–9.4% | .0004 |
| Three serotypes | 8 | 12.5% | 6.2%–23.0% | 0 | 0.0% | .0%–5.6% | .001 |
Abbreviation: OPV, oral polio vaccine.
a 95% confidence interval for a proportion calculated using the modified Wald method.
* Fisher exact test for differences between shedding from direct vaccination vs community acquisition.