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. 2011 Spring;4(2):43–52.

Figure 1.

Figure 1

The Wnt signaling pathway. (A) In the absence of WNT binding to frizzled,dishevelled remains unactivated and β-catenin is targeted for degradtion via the adenomatous polyposis coli/axin/glycogen-synthase-kinase 3β pathway. (B) When Wnt binds to frizzled(right), dishevelled is activated and uncouples β-catenin from the adenomatous polyposis coli; β-catenin can then associate with transcription factors and mediate transcription of the target gene. PC, adenomateous polyposis coli; Dsh, dishevelled; GSK-3β, glycogen synthase kinase 3β; LEF, lymphoid enhancer-binding factor, LRP, LDL-receptor-related protein; P, phosphorylation; TCF, T-cell factor (51).