Table 1.

Summary of clinicopathology and genetic alterations of various colorectal carcinogenesis pathways

	Sporadic	HNPCC	CAC	Serrated pathway	Sporadic indonesia?
Age	>60 years	<40 years		Young	Young
Location	Distal	Proximal		Proximal	Distal
Pathway	Adenoma-carcinoma	Adenoma-carcinoma	Inflammation-dysplasia-cancer	Hyperplastic polyp- cancer	Adenoma-carcinoma
CIN					No
Defective MMR protein	No	Yes	No	Yes	Yes
MSI	No	Yes	No	Yes	No
Inflammation	No	No	IBD	No	Non-specific?
Adenoma	Polyp	Polyp	No	Serrated adenoma	Polyp
KRAS mutation	Yes	Yes	Yes	Yes	No
BRAF mutation	No	No	No	Yes	No
COX-2		No	High
NF-κB	Yes	No	Yes	?	Yes