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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: DNA Repair (Amst). 2014 Feb 20;16:11–22. doi: 10.1016/j.dnarep.2014.01.010

Figure 4. XLF and ATM (and DSBR factors) have complementary functions during C-NHEJ.

Figure 4

(A) ATM (pink oval) may function to hold DNA ends, while XLF (orange circle) stimulates XRCC4/Lig4 (orange and yellow ovals) activity.

(B) ATM may stimulate XRCC4/Lig4, while XLF/XRCC4 filaments hold DNA ends.