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. 2014 Apr 14;79(9):4018–4024. doi: 10.1021/jo5004967

Table 2. Optimization for the Synthesis of Product 3a.

graphic file with name jo-2014-004967_0008.jpg

entry cat. (mol %) additive (mol %) solvent yielda (%)
1 CuI (10) pyridine (30) EtOH 18
2 CuI (10) pyridine (30) CH2Cl2 45
3 CuI (10) 1,10-phen (30) CH2Cl2 56
4 CuI (5) 1,10-phen (15) CH2Cl2 42
5 CuI (20) 1,10-phen (60) CH2Cl2 56
a

Isolated yield.