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. 2014 Apr 4;136(17):6276–6287. doi: 10.1021/ja411855d

Table 4. Scope of Aryl Chlorides in Pd–NiXantphos-Catalyzed DCCP with 1aa.

2.6.

2.6.

a

Reactions conducted on a 0.1 mmol scale using 1.2 equiv of 1a, 3 equiv of KN(SiMe3)2, and 1 equiv of 2 (conditions A) or 1 equiv of 1a, 3 equiv of KN(SiMe3)2, and 2 equiv of 2 (conditions B) using 2.5–10 mol % Pd(OAc)2 and NiXantphos (Pd:L = 1:2) in THF at 0.2 M at 24 °C. Isolated yield after chromatographic purification.

b

1a:KN(SiMe3)2:2 = 4:2:1.

c

CPME was used as solvent.

d

80 °C.

e

1a:KN(SiMe3)2:2 = 1:3:3.

f

2-MeTHF was used as solvent.

g

1a:KN(SiMe3)2:2 = 1.2:4:1.

h

1a:KN(SiMe3)2:2 = 3:4:1.

i

1a:KN(SiMe3)2:2 = 1:5:2.