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. 2014 Apr 25;3:e01381. doi: 10.7554/eLife.01381

Table 1.

Replication analysis

DOI: http://dx.doi.org/10.7554/eLife.01381.016

Test Threshold Associations (available for testing in GEUVADIS) Replicate, FDR <0.05 (% success) Same direction of effect (% success) π1
v-eQTL FDR <0.05 508 (485) 28 (5.8%) 26 (93%) 0.30
v-eQTL Bonf <0.05 23 (23) 16 (70%) 15 (94%) 0.72
Epistasis Bonf <0.05 256 (246) 137 (56%) 131 (96%) 0.71

Significant associations (at FDR and Bonferroni thresholds) from the TwinsUK sample were replicated in GEUVADIS samples. The number of overlapping SNPs and genes in both datasets per analysis is shown, as well as the percentage of replicated associations. π1 is an estimate of the proportion of replicating loci in the GEUVADIS cohort (Storey, 2002).