Table 1.
Test | Threshold | Associations (available for testing in GEUVADIS) | Replicate, FDR <0.05 (% success) | Same direction of effect (% success) | π1 |
---|---|---|---|---|---|
v-eQTL | FDR <0.05 | 508 (485) | 28 (5.8%) | 26 (93%) | 0.30 |
v-eQTL | Bonf <0.05 | 23 (23) | 16 (70%) | 15 (94%) | 0.72 |
Epistasis | Bonf <0.05 | 256 (246) | 137 (56%) | 131 (96%) | 0.71 |
Significant associations (at FDR and Bonferroni thresholds) from the TwinsUK sample were replicated in GEUVADIS samples. The number of overlapping SNPs and genes in both datasets per analysis is shown, as well as the percentage of replicated associations. π1 is an estimate of the proportion of replicating loci in the GEUVADIS cohort (Storey, 2002).