Table 2.
Isoniazid resistance- associated mutations detected in M. tuberculosis study isolates
| Gene | N° of isolates tested | N° of isolates with indicated genotype | Nucleotide change | Amino acid change | N° of mutated isolates according to INH resistance level | |
|---|---|---|---|---|---|---|
| |
|
|
|
|
Low level (0.2 μg/ml) |
High level (1 μg/ml) |
|
katG |
44 INHR |
18 |
315AGC → ACC |
Ser → Thr |
2 |
16 |
| 1 |
315AGC → AAC |
Ser → Asn |
0 |
1 |
||
| 1 |
Partial deletion |
NA |
0 |
1 |
||
| |
24 |
WT |
NA |
0 |
0 |
|
| 100 INHS |
0 |
WT |
NA |
NA |
NA |
|
|
fabG1-inhA regulatory region |
44 INHR |
13 |
-15C → T |
NA |
10 |
3 |
| 5 |
-47G → C |
NA |
0 |
5 |
||
| |
26 |
WT |
NA |
0 |
0 |
|
| 100 INHS |
24 |
-47G → C |
NA |
NA |
NA |
|
| 3 | -102C → T | NA | NA | NA | ||
NA = not applicable; WT = wild type; INHR = isoniazid resistant isolate; INHS = isoniazid sensitive isolate; N°: number.