Table 4.

Hu14.18K322A Pharmacokinetic Parameters for Course One Based on Two-Compartment Model

Dose (mg/m2 per day)	No. Of Patients	CL (L/day)		Cmax (mg/L)		AUC0- (mg × day/L)		T1/2α (day)		T1/2β (day)		Vc (L)
		Median	Range	Median	Range	Median	Range	Median	Range	Median	Range	Median	Range
2	4	0.87	0.34-1.39	1.37	0.42-2.46	9.37	4.14-16.24	1.41	1.02-1.58	15.11	5.67-23.60	3.52	1.37-6.67
4	3	0.50	0.38-0.57	4.39	2.94-7.46	23.77	17.34-35.98	1.74	1.71-1.75	30.60	29.70-36.00	1.38	1.19-1.99
6	5	0.83	0.57-1.48	5.42	4.90-7.54	34.71	30.81-50.80	1.45	1.10-1.96	11.50	4.89-17.40	3.00	2.17-5.57
10	3	0.75	0.61-0.99	8.94	6.42-9.21	53.77	43.32-57.82	1.67	0.95-2.16	13.50	13.30-68.30	2.36	2.01-4.00
20	3	0.82	0.49-0.95	20.09	14.01-20.49	97.17	95.38-129.98	1.70	1.65-1.96	9.52	6.01-128.00	2.34	2.22-3.64
40	3	1.23	0.81-2.20	25.28	23.57-27.11	146.91	127.48-150.31	1.91	1.54-2.15	46.70	36.90-112.00	3.66	2.83-7.83
50	3	0.70	0.60-0.80	46.53	33.45-53.52	231.92	190.61-268.01	1.85	1.33-2.13	62.60	34.50-79.60	2.35	1.77-2.57
60	11	0.72	0.45-1.06	59.15	25.03-74.44	302.10	168.84-428.03	1.85	1.33-2.13	13.50	6.92-201.00	2.08	1.45-4.19
70	2	0.74	0.70-0.77	67.63	61.56-73.70	341.00	326.00-356.00	1.75	1.58-1.92	146.05	21.10-271.00	2.18	1.87-2.49
All	37	0.75	0.34-2.20	23.57	0.42-74.44	129.98	4.14-428.03	1.74	0.95-2.21	21.10	4.89-271.00	2.36	1.19-7.83

Abbreviations: AUC_0-, area under the concentration-time curve from time zero to infinity; C_max, maximum plasma concentration; CL, clearance; T_1/2α, half-life alpha; T_1/2β, half-life beta; V_c, volume of distribution.