Table 2.
Genotype and allele frequencies of STAT3 polymorphisms and their associations with GC risk.
| Genotypes | Cases (N = 209) | Controls (N = 294) | OR (95% CI) | P value | ORadj (95% CI)a | P value |
|---|---|---|---|---|---|---|
| Number (%) | Number (%) | |||||
| rs2293152 | ||||||
| GG | 56 (26.8) | 74 (25.2) | 1.00 | 1.00 | ||
| CG | 94 (45.0) | 157 (53.4) | 0.79 (0.51–1.22) | 0.287 | 0.87 (0.54–1.41) | 0.540 |
| CC | 59 (28.2) | 63 (21.4) | 1.24 (0.75–2.03) | 0.400 | 1.40 (0.81–2.42) | 0.330 |
| CG/CC | 0.92 (0.61–1.38) | 0.681 | 1.03 (0.66–1.62) | 0.893 | ||
| rs744166 | ||||||
| TT | 101 (48.3) | 107 (36.4) | 1.00 | 1.00 | ||
| TC | 89 (42.6) | 142 (48.3) | 0.66 (0.45–0.97) | 0.035 | 0.60 (0.39–0.92) | 0.020 |
| CC | 19 (9.1) | 45 (15.3) | 0.45 (0.25–0.82) | 0.009 | 0.41 (0.21–0.80) | 0.009 |
| TC/CC | 0.61 (0.43–0.88) | 0.008 | 0.55 (0.37–0.83) | 0.004 |
OR: odds ratio; CI: confidence interval.
aAdjusted for age, sex, smoking, drinking, BMI, and family history of cancer.