Table 3.
Stratified analyses of rs744166 genotypes between GC cases and controls.
| Variables | rs744166 | P value | |
|---|---|---|---|
| TT | TC+CC | ||
| Age (years) | |||
| <60 | |||
| Cases/controls | 48/61 | 58/101 | |
| ORadj (95% CI)a | 1.00 | 0.64 (0.37–1.13) | 0.127 |
| ≥60 | |||
| Cases/controls | 53/46 | 50/86 | |
| ORadj (95% CI)a | 1.00 | 0.49 (0.26–0.90) | 0.021 |
| Sex | |||
| Male | |||
| Cases/controls | 77/73 | 81/128 | |
| ORadj (95% CI)a | 1.00 | 0.54 (0.32–0.88) | 0.014 |
| Female | |||
| Cases/controls | 24/34 | 27/59 | |
| ORadj (95% CI)a | 1.00 | 0.63 (0.28–1.40) | 0.254 |
| Smoking statusb | |||
| Never | |||
| Cases/controls | 32/58 | 39/96 | |
| ORadj (95% CI)a | 1.00 | 0.56 (0.29–1.07) | 0.081 |
| Ever | |||
| Cases/controls | 68/48 | 69/91 | |
| ORadj (95% CI)a | 1.00 | 0.54 (0.32–0.93) | 0.026 |
| Alcohol consumption | |||
| Nondrinkers | |||
| Cases/controls | 39/69 | 46/103 | |
| ORadj (95% CI)a | 1.00 | 0.73 (0.40–1.31) | 0.288 |
| Drinkers | |||
| Cases/controls | 62/38 | 62/84 | |
| ORadj (95% CI)a | 1.00 | 0.38 (0.21–0.70) | 0.002 |
| Family history of cancerbc | |||
| No | |||
| Cases/controls | 76/102 | 81/178 | |
| ORadj (95% CI)a | 1.00 | 0.55 (0.36–0.85) | 0.007 |
| Yes | |||
| Cases/controls | 22/4 | 25/8 | |
| ORadj (95% CI)a | 1.00 | 0.50 (0.11–2.28) | 0.371 |
OR: odds ratio; CI: confidence interval.
aAdjusted for age, sex, smoking, drinking, BMI, and family history of cancer.
bMissing data: smoking: 2; family history of cancer: 7.
cFamily history of cancer: gastric, esophageal, liver, colorectal, and other cancers.