Table 4.
Associations between specific autoantibodies and clinical manifestations of SLE [patient number (%)].
| Anti-dsDNA | Anti-Sm | Anti-RNP | Anti-SSA | Anti-SSB | Anti-rRNP | APL | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Positive | P | Positive | P | Positive | P | Positive | P | Positive | P | Positive | P | Positive | P | |
| Patients number | 699 (100) |
350 (100) |
189 (100) |
497 (100) |
224 (100) |
255 (100) |
414 (100) |
|||||||
| Malar rash | 315 (45.06) |
0.061 | 201 (57.43) |
<0.001* | 91 (48.15) |
0.956 | 241 (48.49) |
0.785 | 105 (46.88) |
0.732 | 151 (59.22) |
0.004* | 187 (45.17) |
0.275 |
| Discoid lesions | 31 (4.43) |
0.099 | 22 (6.29) |
0.546 | 13 (6.88) |
0.426 | 25 (5.03) |
0.522 | 11 (4.91) |
0.631 | 13 (5.10) |
0.855 | 20 (4.83) |
0.540 |
| Photosensitivity | 150 (21.46) |
0.008* | 95 (27.14) |
0.311 | 47 (24.87) |
0.965 | 132 (26.56) |
0.358 | 67 (29.91) |
0.073 | 69 (27.06) |
0.752 | 96 (23.19) |
0.509 |
| Oral ulcerations | 151 (21.6) |
0.671 | 87 (24.86) |
0.181 | 42 (22.22) |
0.980 | 108 (21.73) |
0.797 | 48 (21.43) |
0.784 | 48 (18.82) |
0.395 | 74 (17.87) |
0.035* |
| Arthritis | 399 (57.08) |
0.095 | 193 (55.14) |
0.796 | 106 (56.08) |
0.650 | 268 (53.92) |
0.762 | 119 (53.13) |
0.658 | 146 (57.25) |
0.765 | 236 (57.00) |
0.289 |
| Serositis | 119 (17.02) |
0.584 | 55 (15.71) |
0.705 | 31 (16.40) |
0.999 | 89 (17.91) |
0.298 | 46 (20.54) |
0.077 | 35 (13.73) |
0.428 | 61 (14.73) |
0.996 |
| Nephropathy | 355 (50.79) |
0.030* | 155 (44.29) |
0.196 | 91 (48.15) |
0.837 | 216 (43.46) |
0.042* | 102 (45.54) |
0.547 | 120 (47.06) |
0.817 | 191 (46.14) |
0.848 |
| Hematological involvement | 403 (57.65) |
0.321 | 196 (56.00) |
0.957 | 108 (57.14) |
0.769 | 278 (55.94) |
0.920 | 141 (62.95) |
0.030* | 137 (53.73) |
0.542 | 273 (65.94) |
<0.001* |
| Neurological involvement | 26 (3.72) |
0.102 | 18 (5.14) |
0.743 | 12 (6.35) |
0.296 | 21 (4.23) |
0.493 | 13 (5.80) |
0.457 | 16 (6.27) |
0.335 | 32 (7.73) |
0.061 |
| ILD | 29/675$
(4.30) |
0.941 | 18/326$
(5.52) |
0.214 | 11/181$
(6.08) |
0.201 | 21/481$
(4.37) |
0.884 | 12/209$
(5.74) |
0.259 | 12/250$
(4.80) |
0.940 | 29/398$
(7.29) |
<0.001* |
| PAH | 24/661$
(3.63) |
0.747 | 16/322$
(4.97) |
0.242 | 12/180$
(6.67) |
0.037* | 28/469$ (5.97) | 0.005* | 11/205$
(5.37) |
0.224 | 5/237$
(2.11) |
0.151 | 15/387$
(3.88) |
0.714 |
P: P value; Anti-dsDNA: Anti-double stranded DNA antibody; Anti-Sm: Anti-Sm antibody; Anti-SSA: Anti-SSA antibody; Anti-SSB: Anti-SSB antibody; Anti-RNP: Anti-u1 small-nuclear RNA-protein antibody; Anti-rRNP: Anti-ribosomal RNA-protein antibody; APL: Anti-phospholipid antibody; PAH: pulmonary arterial hypertension; ILD: interstitial lung disease.
$Actually detected number of patients.
*P < 0.05.