Table 2.

Studies investigating the effect of thyroxine treatment on psychological well-being in subclinical hypothyroidism

Study	n (treated/placebo)	Duration	Measure	Result
Jorde et al. [38]	36/33	1 year	BDI, GHQ-30	ns
Jaeschke et al. [39]	18/19	>6 months	CTQ, SIP	ns
Kong et al. [40]	23/17	6 months	HADS, GHQ-30	ns
Meier et al. [41]	31/32	50 weeks	Billewicz/Zulewski scores	significant improvement only in those with TSH >12
Gulseren et al. [21]	36/0	9–10 months	BDQ, HDRS, SF-36	improved to control group
Baldini et al. [42]	38/0	6 months	SF36	improved to control group

BDI = Becks depression index; GHQ = general health questionnaire; CTQ = chronic thyroid questionnaire; SIP = sickness impact profile; HADS = hospital anxiety and depression score, BDQ = brief disability questionnaire, HDRS = hamilton depression rating scale; SF-36 = short form 36.