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. Author manuscript; available in PMC: 2014 May 14.
Published in final edited form as: Nature. 2013 Oct 30;503(7475):224–228. doi: 10.1038/nature12744

Figure 2. Therapeutic efficacy of the double PGT121/3BNC117 mAb cocktail.

Figure 2

Plasma viral RNA (log copies/ml) in rhesus monkeys chronically infected with SHIV-SF162P3 following a single infusion (arrows) of PGT121, 3BCN117, and b12 (a); PGT121 and 3BNC117 (b); or the control mAb DEN3 (c). d, Plasma viral RNA in monkeys that received PGT121 and 3BNC117 following a second infusion on day 105. PD-1+Ki67+ expression on Gag-specific CD8+ (e) and CD4+ (f) T lymphocytes in the monkeys that received PGT121 and 3BNC117. Proviral DNA (copies/106 cells) in lymph nodes (g) and gastrointestinal mucosa (h) before (day 105) and 14 days after (day 119) the second mAb infusion with PGT121 and 3BNC117 in the four animals with detectable viremia.