Table 1.
Baseline demographics, clinical and ADRB2 genotype characteristics
| FGID (n = 170) | Healthy controls (n = 228) | P value | |
|---|---|---|---|
| Age, mean ± S.E.M. | 43.9 ± 6.3 | 54.2 ± 1.1 | 0.08 |
| Female gender (%) | 135 (79.4) | 138 (60.5) | <0.001 |
| Total no. Rome III diagnoses | 1.6 ± 0.04 | N/A | |
| Irritable bowel syndrome (IBS)* | 139 (34.9) | ||
| IBS-D | 44 (11.0) | ||
| IBS-C | 18 (4.5) | ||
| IBS-M | 77 (19.3) | ||
| Functional dyspepsia (FD) | 136 (34.1) | ||
| Postprandial distress (PDS) | 85 (21.3) | ||
| Epigastric pain syndrome (EPS) | 92 (23.1) | ||
| Functional chest pain | 25 (6.2) | ||
| GI symptom severity [VAS] | 7.2 ± 0.1 | ||
| GI Symptom bother [VAS] | 7.1 ± 0.2 | ||
| GI Symptom frequency [days/last 2 weeks] | 9.7 ± 0.3 | ||
| SF36 total† | 49.0 ± 1.7 | 70.0 ± 2.3 | <0.001 |
| SF36 physical | 42.8 ± 1.8 | 63.9 ± 2.6 | <0.001 |
| SF36 mental | 50.7 ± 1.8 | 70.4 ± 1.8 | <0.001 |
| Any extraintestinal functional diagnoses (EIFD)‡ | 100 (59.9) | 45 (19.9) | <0.001 |
| No. extraintestinal functional diagnoses (EIFDs), mean | 1.5 ± 0.2 | 0.7 ± 0.2 | <0.001 |
| Any psychiatric diagnosis‡ | 90 (53.9) | 60 (26.5) | <0.001 |
| Depression | 70 (41.9) | 44 (19.5) | <0.001 |
| Anxiety disorder | 55 (32.9) | 27 (11.9) | <0.001 |
| ADRB2 genotypes§ | |||
| rs1042713 | |||
| AA | 24 (14.9) | 44 (20.8) | 0.15 |
| AG | 82 (50.9) | 105 (49.5) | |
| GG | 55 (34.2) | 63 (29.7) | |
| rs1042714 | |||
| GG | 29 (18.0) | 24 (10.8) | 0.004 |
| CG | 81 (50.3) | 99 (44.6) | |
| CC | 51 (31.7) | 99 (44.6) | |
*
Percentages listed for individual FGIDs reflect an overall percentage within the entire study cohort.
†
SF36 data were available in most FGID subjects (n = 165), but only in a subset (n = 71) of healthy controls.
‡
EIFD and psychiatric diagnosis data were unavailable in 5 individuals (3 healthy controls, and 2 FGID subjects).
§
ADRB2 genotyping was unsuccessful for rs1042714 in 15 subjects (9 FGID, 6 controls) and for rs1042713 in 25 subjects (9 FGID and 16 controls). Percentages shown apply the total number of individuals successfully genotyped as the denominator.