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Histopathological scoring of the tissue of PCM-induced hepatic injury rats after pretreatment with MEMC.
| Treatment | Dose (mg/kg) | Steatosis | Necrosis | Inflammation | Haemorrhage |
|---|---|---|---|---|---|
| Normal | − | − | − | − | − |
| 10% DMSO + PCM | − | +++ | ++ | ++ | |
| NAC + PCM | 50 | − | + | + | − |
| MEMC + PCM | 50 | − | ++ | + | + |
| 250 | − | + | + | − | |
| 500 | − | + | + | − |
The severity of various features of hepatic injury was evaluated based on those following scoring schemes: − normal, + mild effect, ++ moderate effect, and +++ severe effect.
