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. 2014 Apr 23;11:19. doi: 10.1186/1743-7075-11-19

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Copyright © 2014 Mobley et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Top IPA liver gene network altered in WD + AF versus WD rats compared to CTL rats. Notably, relative to WD/CTL comparisons, WD + AF/CTL comparisons demonstrated a significant up-regulation in Cd36 (fatty acid transport) and down-regulation of Pck1 and Slc2a2 (both of which are involved with gluconeogenesis and glucose transport, respectively). Left inset is a diagram of the top liver gene network significantly altered (up- and down-regulated): ‘Gene Expression, Carbohydrate Metabolism, Molecular Transport’ (score: 29; up-regulated mRNAs: Ltb, Nr0b2, Cd36, Foxoa2, Hnf3; down-regulated mRNAs: Pepck, Pck1, Slc2a2, Ahr, Ivns1abp). Right inset is the legend for transcript function, degree of up-regulation/down-regulation, and interactive symbols.