Table 2.
Main Effects of Environmental and Genetic Factors on Alcoholism With Multinomial Logistic Regression Controlling for the Effect of Gender, Age, and Smoking Status
| Overall | MAXDRINKS ≥ 36 | ||||||
|---|---|---|---|---|---|---|---|
| Factors | Controls/ alcoholics |
p-Value | OR (95% CI) | Control/ alcoholics |
p-Value | OR (95% CI) | |
| Marital status | Single | 185/215 | 0.254 | NA | 185/68 | 0.446 | NA |
| Married | 120/113 | 120/36 | Reference | ||||
| Living with a partner | 16/29 | 16/10 | 0.183 | ||||
| Duration of education | ≤12 years | 212/286 | 0.002 | 1.792 (1.236–2.604) | 212/96 | 0.019 | 1.966 (1.117–3.461) |
| >12 years | 111/75 | Reference | 111/21 | Reference | |||
| 5-HTTLPR | S/S | 108/136 | 0.373 | NA | 108/51 | 0.082 | NA |
| S/L & L/L | 230/229 | 230/67 | |||||
| OPRM1 | A/A | 198/230 | 0.292 | NA | 198/88 | 0.003 | 2.162 (1.300–3.597) |
| A118G A/G & G/G | 140/135 | 140/30 | Reference | ||||
| DRD2−141C | Ins/Ins | 235/270 | 0.111 | NA | 235/94 | 0.030 | 1.847 (1.062–3.211) |
| Ins/Del | Ins/Del & Del/Del | 103/95 | 103/24 | Reference | |||
| MAXDRINKS | 23–35 MAXDRINKS ≤ 22 | ||||||
|---|---|---|---|---|---|---|---|
| Factors | Controls/ alcoholics |
p-Value | OR (95% CI) | Control/ alcoholics |
p-Value | OR (95% CI) | |
| Marital status | Single | 185/75 | 0.180 | NA | 185/70 | 0.971 | NA |
| Married | 120/34 | Reference | 120/43 | Reference | |||
| Living with a partner | 16/11 | 0.051 | 16/8 | 0.677 | |||
| Duration of education | ≤12 years | 212/98 | 0.01 | 2.032 (1.186–3.481) | 212/90 | 0.155 | NA |
| >12 years | 111/22 | Reference | 111/32 | ||||
| 5-HTTLPR | S/S | 108/46 | 0.396 | NA | 108/38 | 0.552 | NA |
| S/L & L/L | 230/75 | 230/86 | |||||
| OPRM1 | A/A | 198/71 | 0.952 | NA | 198/70 | 0.605 | NA |
| A118G | A/G & G/G | 140/50 | 140/54 | ||||
| DRD2−141C | Ins/Ins | 235/82 | 0.926 | NA | 235/93 | 0.160 | NA |
| Ins/Del | Ins/Del & Del/Del | 103/39 | 103/31 | ||||