Table 2.

Multivariable regression coefficients between covariables and renin/aldosterone

Variable	Renin (per SD)				Aldosterone (per SD)
	Coefficient	95% confidence limits		P value	Coefficient	95% confidence limits		P value
Age, per 10 y	−0.08	−0.16	0.01	0.07	−0.14	−0.23	−0.06	0.001
Male sex	0.27	0.11	0.42	0.0007	−0.13	−0.29	0.02	0.09
Systolic BP, per 10mm Hg	−0.09	−0.14	−0.04	0.0002	−0.05	−0.09	0.00	0.07
Diastolic BP, per 10mm Hg	−0.01	−0.10	0.09	0.92	0.16	0.06	0.25	0.001
Hyperlipidemiaa	0.03	−0.11	0.16	0.67	0.19	0.06	0.33	0.006
Diabetes	0.14	−0.09	0.37	0.24	0.06	−0.17	0.30	0.60
Waist-to-hip ratio, per SD	0.02	−0.06	0.10	0.60	0.09	0.01	0.17	0.03
eGFR, per 10	−0.02	−0.06	0.03	0.53	−0.08	−0.13	−0.03	0.001
Estrogen replacement	0.16	−0.08	0.39	0.19	0.20	−0.04	0.44	0.10
Alcohol	0.02	−0.11	0.15	0.78	0.12	−0.01	0.25	0.08

Coefficients reported are from multivariable regression with all covariables of model 3 included (see Methods).

^aDefined as cholesterol/high-density lipoprotein >5 or taking lipid-lowering medication.