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. Author manuscript; available in PMC: 2014 May 12.
Published in final edited form as: Nat Commun. 2012 Apr 24;3:790. doi: 10.1038/ncomms1789

Figure 4. Spatial regulation of dADAR auto-editing.

Figure 4

(a) Total auto-editing levels at a wild-type dAdar locus in combination with engineered mutations in dAdar auto-editing. dAdarS hemi- and homozygotes are defined as having 0 % auto-editing, while dAdarG is 100 %. Auto-editing levels in the remaining allelic combinations were determined experimentally (Methods). L – wild-type LoxP allele. (b) Auto-editing levels in dAdarWTLoxP male and female head and thoracic tissues. n = 5–8 PCRs. *: P < 0.05, **: P < 0.005, Mann-Whitney U-test. (c) Correlation between the reduction in editing at 18 adenosines in dAdarG and dAdarhyp male heads. Error bars, s.e.m.