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. 2011 Mar 8;2(5):342–347. doi: 10.1021/ml200025q

Figure 2.

Figure 2

X-ray crystal structure of 17 in complex with B-RafWT. Notation is as described for Figure 1. In addition to the hydrogen-bonding interactions described in Figure 1, the sulfonamide NH of 17 is in close contact to the main chain NH of Asp594, indicating that the sulfonamide is deprotonated.23