Table 1. Enzymatic and Cellular Activities of B-Raf^V600E Amide Series Inhibitors.

	IC50 (nM)
compd	enzymea	Malme-3Mb	A375b
3	3900	6700	>3000
4	920	2400	>3000
5	110	310	1200
8	61	2400	>3000
9	38	94	290
10	3.4	39	190
13	17	62	430
14	4.0	44	260
15	12	86	830
16	8.2	40	650
17	4.8	19	150
18	6.3	56	560
19	1.7	20	240
1	31c	61	190

^aBiochemical assay (B-Raf^V600E).

^bCellular phosphorylation assay (pERK) using B-Raf^V600E mutant Malme-3M or A375 cell line.

^cRef (23).