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. 2011 Mar 8;2(5):342–347. doi: 10.1021/ml200025q

Table 2. Mouse Pharmacokinetics and Physicochemical Properties of Pyrrolo- and Pyrazolopyridine Amides.

compd	30 mg/kg po AUC^a (% F)	100 mg/kg po AUC^a (% F)	CL^b	Vd^c	mouse PPB^d	mp (°C)	sol. at pH 6.5, 7.4^e
9	200 (76)		1.9	0.20	97.9	243	1, 4
10	49 (71)		7.2	0.24	99.4	227	<1, <1
13	40 (100)		15	0.68	87.1	173	80, 150
14	52.5				98.4	220	1, 3
15	18.3				89.9	181	380, 740
16	1.09				90.8	181	290, 450
17	190 (48)	664 (51)	1.3	0.11	97.4	229	4, 9
18	147 (67)		2.3	0.17	97.1	236	15, 48
19	1080 (53)	50.7 (1.2)	1	0.11	99.1	261	<1, 2

^a

μg h/mL.

^b

mL/min/kg.

^c

L/kg.

^d

Plasma protein binding (%).

^e

μg/mL.