Table 4. Pharmacokinetic Parameters for 13 and 19 Estimated in Blood in CD-1 Mice^a.

					area under curve AUC0-t (μg/h/mL)
compd no.	clearance (mL/min/kg)	volume of distribution (L/kg)	half-lifeb (h)	maximum concn Cmaxc (μg/mL)	iv	po	oral bioavailability (% F)
13d	29.7	6.47	2.77	2.34	0.596	9.71	81
19e	14.3	11.9	10.2	1.09	2.23	13.6	55

^aDosing 2 mg/kg iv and 20 mg/kg po into CD-1 mice (n = 4 for both arms).

^biv.

^cpo.

^div vehicle 20% (v:v) encapsine in water, po vehicle 1% (w:v) methylcellulose in water.

^eiv vehicle 3% solutol, 7% PEG (v:v) in saline, po vehicle 1% (w:v) methylcellulose in water.