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. 2011 Jan 12;2(3):207–212. doi: 10.1021/ml1002426

Table 3.

graphic file with name ml-2010-002426_0006.jpg

		Replicon IC₅₀ (nM)^b
compd	1b K_i (nM)^a	1b 10% FBS	1b 50% NHS	2a 10% FBS	rat PO plasma AUC (μM·h)^c	rat [liver] @ 4 h (μM)^d
19	0.05	3.0	60.0	6.0	2.5	13.2
15c	0.03	2.0	80.0	-	18.1	8.0
15j (MK-1220)	0.02	4.0	11.0	5.0	11.8	23.0
14k	0.02	2.0	10.0	11.0	0.18	16.0

^a

NS3/4A protease time-resolved fluorescence assay.

^b

Cell-based replicon assay.

^c

5 mg/kg dosed orally in PEG400 (n = 2); AUC calculated based on 4 h experiment.

^d

5 mg/kg dosed orally in PEG400 (n = 2); liver levels after 4 h.