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| species | Cla (mL/(min kg)) | T1/2a (h) | %F | PObCmax (μM) | POb AUC (μM·h) | POb [liver] (μM) | POb [liver] (μM) |
|---|---|---|---|---|---|---|---|
| rat | 3.4 | 5.7 | 37% | 4.4 | 12.1 | 23 @ 4 h | 9.9 @ 24 h |
| dog | 3.6 | 2.5 | 41% | 4.0 | 12.4 | 54 @ 2 h | 10.3 @ 26 h |
| monkey | 8.3 | 1.3 | 9% | 0.3 | 1.2 |
IV: Rat (n = 4) and dog (n = 2) at 2 mg/kg and monkey (n = 3) at 1 mg/kg; DMSO.
PO (5 mg/kg, n = 3 in rat and n = 2 in dog and monkey; 10% Tween).
