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. 2010 Nov 9;2(2):97–101. doi: 10.1021/ml100227q

Table 2. Lead Optimization of Benzofuran Corea.

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a

Data represents an average of at least two determinations.

b

Compound induced binding of [35S]-GTPγS to human S1P-1 receptors expressed on CHO cell membranes.

c

Percent efficacy is reported relative to 1.0 μM 1-(4-(6-benzylbenzofuran-2-yl)-3-fluorobenzyl)azetidine-3-carboxylic acid 18 (for hS1P1 RI); NA, not available.