Table 3. Mean Compound 18 PK Parameters in Pie Clinical Species.
| species | CL (L/h/kg) | Vss (L/kg) | T1/2,Z (h) | MRT (h) | F % |
|---|---|---|---|---|---|
| rata | 0.138 | 1.7 | 12.1 | 12.7 | 80 |
| NHPb | 0.309 | 1 | 4.7 | 3.4 | 88 |
| caninec | 0.266 | 2.2 | 21.1 | 9 | 51 |
a
Male Sprague−Dawley (iv: 1 mg/kg, DMSO, N = 3; po: 3 mg/kg, 20% captisol, pH 4.0, N = 3).
b
NHP = nonhuman primate, male cynomolgus (iv: 1 mg/kg, 5% hydroxypropyl-β-cyclodextrin, N = 3; po: 5 mg/kg, 5% hydroxypropyl-β-cyclodextrin, N = 3.).
c
Male beagle (iv: 2 mg/kg, 20% captisol, pH 4.0, N = 3; po: 3 mg/kg, 20% captisol, pH 4.0, N = 3).