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. 2011 Mar 17;2(5):353–357. doi: 10.1021/ml100292y

Table 1. SAR Studies on the COXs Inhibition by 1a−d (n = 3).

	COX-1		COX-2
compound	ihibition (100 μM, %)	IC₅₀ (μM)	ihibition (100 μM, %)	IC₅₀ (μM)
1a (synthesized)	81 ± 11	0.01	89 ± 0.7	18
1b^a	79 ± 6.4	0.01	76 ± 1.4	39
1c	<0	>400	14 ± 0.9	>400
1d	<0	>400	13 ± 2.0	>400
1a (purchased)	110 ± 11	0.12	83 ± 0.45	20
aspirin	38 ± 3.1	>100	2 ± 1.5	>400

^a

These data are in accord with those reported previously.²⁰