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. 2011 Jan 11;2(3):224–229. doi: 10.1021/ml1002647

Table 3. Effect of Variation of the 2-Furyl and 3-Fluorophenyl Moieties in Both the l-Alanine and l-Proline Series on Antiviral Activity in a HCV Genotype 1b Replicon.

graphic file with name ml-2010-002647_0008.jpg

R1 R2 cmpd AA = l-alanine EC50 (μM)a cmpd AA = l-proline EC50 (μM)a
2-tetrahydrofuranyl 3-F-C6H4 22 0.65    
2-pyrazinyl 3-F-C6H4 23 0.025 24 0.038
2-pyridinyl 3-F-C6H4 25 0.035 26 0.002
3-pyridinyl 3-F-C6H4 27 0.026    
2,3,4-F3-C6H2 3-F-C6H4 28 0.55 29 0.6
2-furyl 4-CF3-C6H4 30 2.2 31 0.98
2-furyl 3-F-4-CF3-C6H3 32 2.5 33 2.2
2-furyl 4−Cl-C6H4 34 0.51 35 1.17
2-furyl 4-Et-C6H4 36 1.5 37 1.8
2-furyl 4-CN-C6H4 38 0.037 39 0.086
2-furyl graphic file with name ml-2010-002647_0009.jpg 40 0.01 41 0.009
2-furyl 5-quinolinyl 42 0.02 43 0.01
2-furyl 4-morpholinylphenyl 44 0.015 45 0.02
a

EC50 values are averages of at least two independent determinations.